11/25/2020 / By Evangelyn Rodriguez
Chinese researchers investigated the anti-fibrotic effects of curcumin on epithelial-to-mesenchymal transition (EMT) induced by transforming growth factor-B1 (TGF-B1), as well as the mechanism by which it influences the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Their findings were published in the journal Biological and Pharmaceutical Bulletin.
Based on these findings, the researchers concluded that curcumin is an alternative treatment for renal fibrosis because it can promote HKC proliferation and stop EMT by inhibiting the activation of the Akt/mTOR pathway activity.
Journal Reference:
Zhu FQ, Chen MJ, Zhu M, Zhao RS, Qiu W, Xu X, Liu H, Zhao HW, Yu RJ, Wu XF et al. CURCUMIN SUPPRESSES EPITHELIAL–MESENCHYMAL TRANSITION OF RENAL TUBULAR EPITHELIAL CELLS THROUGH THE INHIBITION OF AKT/MTOR PATHWAY. Biological and Pharmaceutical Bulletin. 2017;40(1):17-24. DOI: 10.1248/bpb.b16-00364
Tagged Under:
alternative medicine, anti-fibrotic, curcumin, disease treatment, kidney health, natural cures, natural medicine, phytonutrients, remedies, renal fibrosis, research
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